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if results of in vitro susceptibility testing indicate that a clinical isolate is resistant to cefixime, the strain is not inhibited by systemic concentrations of the drug achievable with normal dosage schedules and or mics fall in the range where specific microbial resistance mechanisms are likely and efficacy has not been reliable in clinical studies.
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three studies have evaluated the use of cefixime as the oral component of cephalosporin-based intravenous to oral switch regimens a relatively new cost saving strategy in hospitalised patients with lrti.
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however, the efficacy of cefixime trihydrate in treating clinical infections caused by these bacteria has not been established in adequate and well-controlled clinical trials.
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prescribing suprax cefixime in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
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