In the absence of detailed information on the pre-existing history of individual acute and tardive extrapyramidal movement disorders, it can not be concluded at present that olanzapine produces less tardive dyskinesia and or other tardive extrapyramidal syndromes.
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drugs with a possible risk for qt prolongation and tdp that should be used cautiously with risperidone include olanzapine.
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cyp2d6 mediated oxidation appears to be a minor metabolic pathway in vivo, because the clearance of olanzapine is not reduced in subjects who are deficient in this enzyme.
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