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they can interact with isoniazid and rifampin and cause a reaction that includes a severe headache, large pupils, neck stiffness, nausea, vomiting, diarrhea, flushing, sweating, itching, irregular heartbeats, and chest.
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isoniazid 10-15 mg kg day for 9 months isoniazid 20-40 mg kg twice weekly for 9 months rifampin 10-20 mg kg day for 6 months.
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the impact on survival and incidence of tuberculosis was similar for isoniazid three times a week or once a day.
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